By Emma Court, Robert Langreth and Matthew Griffin<\/strong>
\n\t\u00a0<\/p>\n
\n\tObesity shots like Wegovy are already a cultural phenomenon. Now it\u2019s looking like pill forms of the drugs from Eli Lilly & Co. and Novo Nordisk A\/S are just as good at helping people lose weight, setting the stage for even more explosive growth in the years ahead.
\n\t\u00a0<\/p>\n
\n\tNovo and Lilly\u2019s experimental obesity pills helped people lose about 15% of body weight, similar to weight-loss shots on the market already, according to findings presented at the American Diabetes Association\u2019s conference over the weekend. Meanwhile, Pfizer Inc. said it will discontinue one of its weight loss pills under development as safety concerns arose.\u00a0<\/p>\n
\n\tDrugmakers have been rushing to develop obesity drugs, angling for a piece of a market that some estimate will one day be worth as much as $100 billion. Novo\u2019s Wegovy injection has been available since 2021 and Lilly\u2019s diabetes shot Mounjaro could be cleared on the US market for obesity soon: now, the next frontier is developing easy-to-take pill versions.<\/p>\n
\n\t\u201cLilly and Novo remain at the forefront\u201d in developing pill forms of weight-loss drugs, said Richard DiMarchi, an obesity researcher at Indiana University. He worked at Lilly for more than 20 years and later sold a company he founded to Novo, but has no current ties to either company. For other companies trying to catch up, \u201cIt will be hard but not impossible,\u201d he said.<\/p>\n
\n\tLilly released its strongest results of any of its treatments yet in a test of retatrutide, a shot that could further boost its efforts to dominate the burgeoning obesity drug market. People with obesity shed an average of 24.2% of their body weight, about 58 pounds, on the highest dose of the drug after 48 weeks, according to a study released Monday by the New England Journal of Medicine.\u00a0<\/p>\n
\n\tAll the new drugs mimic GLP-1, a hormone that makes people feel full and eat less. But each company\u2019s pill version takes a different approach.\u00a0\u00a0<\/p>\n
\n\tNovo\u2019s oral drug is a higher dose of an approved pill, the diabetes medication Rybelsus. Adapting a drug that\u2019s already on the market reduces the risk of a surprise safety problem, said DiMarchi.<\/p>\n
\n\tLilly\u2019s pill looks safe and effective so far, but a lot will depend on what come out of larger, late-stage trials.<\/p>\n
\n\t\u201cIt still needs to be proven that this is truly effective and truly safe for long term use,\u201d DiMarchi said.<\/p>\n
\n\tPfizer Fumble\u00a0<\/p>\n
\n\tPfizer had a setback on its road to developing an obesity pill Monday, halting development of an experimental drug called lotiglipron after seeing high levels of liver enzymes in patients on the drug. Few details are known about precisely what level of enzymes Pfizer saw. Evercore ISI analyst Umer Raffat called it a \u201cbig setback\u201d for the company.\u00a0<\/p>\n
\n\tPfizer is continuing to test another pill called danuglipron that outperformed a placebo in a recent study, producing around 9 more pounds of weight loss at the highest dose. \u201cSure they\u2019ll move ahead with danuglipron,\u201d Raffat said in a note to investors, \u201cbut it\u2019s not the best shot they had.\u201d<\/p>\n
\n\tExperts say what happened with Pfizer\u2019s pill isn\u2019t a sign of trouble ahead for the other companies\u2019 oral treatments. Still Pfizer\u2019s shares were down as much as 5.6% Monday, as investors considered other issues with the therapy.\u00a0<\/p>\n
\n\tDanuglipron currently must be taken twice a day, and that could \u201cprove challenging, assuming all else is equal, leaving Pfizer\u2019s $10 billion peak sales estimate for danuglipron looking optimistic,\u201d Bloomberg Intelligence analysts John Murphy and Mila Bankovskaia said. Pfizer said it sticks by its estimate for peak sales.\u00a0<\/p>\n
\n\tThe company is also looking at developing a once-daily version that could be moved into late-stage testing, a Pfizer spokesperson said.<\/p>\n
\n\tWall Street analysts don\u2019t expect Lilly and Novo\u2019s pills to have the same problems as Pfizer\u2019s drug. And all the oral drugs are likely years away from becoming commercially available. But major differences already emerging between the two could set Lilly\u2019s medicine up for greater success.\u00a0<\/p>\n
\n\tLilly\u2019s pill, for instance, helped patients lose as much as 15% of their body weight after around eight months of treatment. Longer use could help patients slim down even more, perhaps losing as much as 20% of their body weight, said Daniel Drucker, a co-discoverer of the GLP-1 hormone who\u2019s a professor of medicine at the University of Toronto.<\/p>\n
\n\tDrucker called the drug \u201cthe star of the show\u201d at the conference. He said it was unprecedented for a pill to produce so much weight loss so quickly.<\/p>\n
\n\t\u2018Thumbs Up\u2019<\/p>\n
\n\t\u201cIn terms of hot new data that was not previously disclosed before, thumbs up to Lilly,\u201d he said.\u00a0<\/p>\n
\n\tRead More: Lilly\u2019s Mounjaro Gives Positive Results in Obese Diabetic People<\/p>\n
\n\tThe Lilly medication also helped reduce levels of certain liver enzymes, Bloomberg Intelligence analyst Michael Shah said. It\u2019s difficult to compare its findings with Pfizer\u2019s given the lack of detail in company releases.\u00a0<\/p>\n
\n\tNovo\u2019s drug, meanwhile, has other limitations. Oral semaglutide uses high doses of a main ingredient, so it\u2019s likely to be harder and more expensive to manufacture large amounts. Also, in studies of Novo\u2019s pill, patients had to fast before taking the drug and then a half an hour afterwards, issues that don\u2019t affect Lilly\u2019s pill.\u00a0<\/p>\n
<\/div>\n
\n
Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
By Emma Court, Robert Langreth and Matthew Griffin
\u00a0
Obesity shots like Wegovy are already a cultural phenomenon. Now it\u2019s looking like pill forms of the drugs from Eli Lilly & Co. and Novo Nordisk A\/S are just as good at helping people lose weight, setting the stage for even more explosive growth […]<\/p>\n","protected":false},"author":1,"featured_media":75521,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_uag_custom_page_level_css":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[42],"tags":[50835,38779,50831,50839,50836,50840,50838,50837,50833,39964,50830,50832,50834],"jetpack_publicize_connections":[],"class_list":{"0":"post-75520","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-healthfitness","8":"tag-causes-of-obesity","9":"tag-diabetes","10":"tag-drugmakers","11":"tag-eli-lilly-co","12":"tag-health-risk-of-obesity","13":"tag-novo-nordisk-a-s","14":"tag-obesity-drug-makers","15":"tag-obesity-medicine","16":"tag-obesity-pills","17":"tag-weight-loss","18":"tag-weight-loss-pills","19":"tag-weight-loss-shots","20":"tag-what-is-obesity"},"yoast_head":"\n
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Obesity shots like Wegovy are already a cultural phenomenon. 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By Emma Court, Robert Langreth and Matthew Griffin
\u00a0
Obesity shots like Wegovy are already a cultural phenomenon. Now it\u2019s looking like pill forms of the drugs from Eli Lilly & Co. and Novo Nordisk A\/S are just as good at helping people lose weight, setting the stage for even more explosive growth […]","og_url":"https:\/\/v99news.com\/obesity-pills-race-to-develop-weight-loss-pills-has-some-drugmakers-falling-behind\/","og_site_name":"v99news.com","article_published_time":"2023-06-27T02:57:12+00:00","og_image":[{"url":"https:\/\/bsmedia.business-standard.com\/_media\/bs\/img\/article\/2023-06\/27\/full\/1687834624-3432.jpg"}],"author":"vrtechllc98","twitter_card":"summary_large_image","twitter_image":"https:\/\/bsmedia.business-standard.com\/_media\/bs\/img\/article\/2023-06\/27\/full\/1687834624-3432.jpg","twitter_misc":{"Written by":"vrtechllc98","Est. reading time":"4 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By Emma Court, Robert Langreth and Matthew Griffin
\u00a0
Obesity shots like Wegovy are already a cultural phenomenon. Now it\u2019s looking like pill forms of the drugs from Eli Lilly & Co. and Novo Nordisk A\/S are just as good at helping people lose weight, setting the stage for even more explosive growth…","jetpack_sharing_enabled":true,"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/posts\/75520"}],"collection":[{"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/comments?post=75520"}],"version-history":[{"count":0,"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/posts\/75520\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/media\/75521"}],"wp:attachment":[{"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/media?parent=75520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/categories?post=75520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/v99news.com\/wp-json\/wp\/v2\/tags?post=75520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}